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Anti-neutrophil cytoplasmic antibody (ANCA) are screened by Indirect Immunofluorescence. Positive samples are automatically tested for the more specific MPO (pANCA) and PR3 (cANCA) enzyme antibodies. cANCA in the absence of PR3 is unlikely to be significant. pANCA in the absence of MPO is commonly associated with inflammatory bowel disease and primary sclerosing cholangitis. • MPA- usually MPO positive - may be PR3 positive • GPA - usually PR3 positive • Churg-Strauss Syndrome usually MPO, may be PR3 positive • Subacute bacterial endocarditis may be cANCA and PR3 positive • Good pasture’s (anti-GBM) may also have ANCA, which is associated with better prognosis.

Other Comments:

Negative