Thyroglobulin is a tumour marker used for monitoring of differentiated thyroid cancer. It is exclusively produced by the thyroid gland, therefore levels should be undetectable following thyroidectomy for thyroid cancer. An increase in thyroglobulin following thyroidectomy may be a sign of disease recurrence.
The presence of thyroglobulin antibodies in a sample may cause assay interference, typically leading to falsely low results. Thyroglobulin antibodies are therefore measured on each sample and antibody levels greater than or equal to 20 IU/ml are sent for a referral laboratory for confirmation by radioimmunoassay.
Available to Oncology only.
Thyroglobulin testing is performed in the local lab on Fridays only.
Reference ranges do not apply to this test. Levels should be undetectable following thyroidectomy and results should be used to assess trends.
For more information, please see the following: Thyroglobulin - Lab Tests Online
Confirmatory radioimmunoassay thyroglobulin analysis for antibody positive samples are sent to Clinical Laboratory Services, Level 1 Clinical Biochemistry, Queen Elizabeth Hospital, Birmingham, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB
Age/gender specific reference ranges provided by referral laboratory
Last updated: Monday 1st August 2022
- Clotted (red top)
Add-on requests are accepted up to 48 hours post sampling